Heteroaromatic Lipoxin A4 Analogues: Synthesis and Biological Evaluation Colm Duffy

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Published: January 10th 2012

Kindle Edition

180 pages


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Heteroaromatic Lipoxin A4 Analogues: Synthesis and Biological Evaluation  by  Colm Duffy

Heteroaromatic Lipoxin A4 Analogues: Synthesis and Biological Evaluation by Colm Duffy
January 10th 2012 | Kindle Edition | PDF, EPUB, FB2, DjVu, AUDIO, mp3, ZIP | 180 pages | ISBN: | 6.28 Mb

In this thesis Colm Duffy reviews the chemistry and biology of stable lipoxin analogues. Colm has prepared for the first time ever a pyridine-containing LXA4 analogue in enantiomerically pure form. Biological evaluation determined that both epimers at the benzylic position suppress key cytokines known to be involved in inflammatory disease, with the (R)-epimer proving most efficacious. Moreover the author developed an excellent route to a related thiophene-containing analogue that also showed interesting biological activity.

Both routes have inspired further work in  the synthesis of further heteroaromatic analogues for biological evaluation.



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